Format

Send to

Choose Destination
Reprod Biol Endocrinol. 2008 Apr 2;6:14. doi: 10.1186/1477-7827-6-14.

Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta.

Author information

1
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. jecaminp@gmail.com

Abstract

BACKGROUND:

Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta.

METHODS:

In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction.

RESULTS:

Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction.

CONCLUSION:

These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.

PMID:
18384674
PMCID:
PMC2386475
DOI:
10.1186/1477-7827-6-14
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center