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Dermatol Surg. 2008 May;34(5):720-6. doi: 10.1111/j.1524-4725.2008.34176.x. Epub 2008 Apr 1.

Rejuvenating influence of a stabilized hyaluronic acid-based gel of nonanimal origin on facial skin aging.

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Division of Cosmetic Sciences, University of Hamburg, Hamburg, Germany.



Skin changes associated with aging, such as loss of elasticity and turgor, can have a negative psychosocial impact. Current treatment options aimed at restoring elasticity are often ineffective or hampered by a poor risk/benefit ratio.


Clinical observations and biophysical measurements were used to assess the effect of middermal placement of stabilized hyaluronic acid-based gel of nonanimal origin (NASHA, Restylane, Vital, Q-Med) on the appearance and elasticity of facial skin.


In this pilot study, 19 female patients underwent a series of three treatment sessions, spaced 4 weeks apart, with NASHA injected into the lower cheeks. Elasticity, skin surface roughness, dermal thickness, and density were evaluated at each treatment session and at 4 and 12 weeks after the last treatment session. Patient satisfaction was assessed, and photographs were taken at each visit.


During the course of the study, skin elasticity and surface roughness improved significantly. Patient feedback was extremely positive.


Micropuncture placement of NASHA can exert a rejuvenating effect on facial skin.

[Indexed for MEDLINE]

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