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Med Phys. 2008 Feb;35(2):446-55.

Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography.

Author information

1
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA. skonecky@physics.upenn.edu

Abstract

We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (18F-FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.

PMID:
18383664
PMCID:
PMC2471877
DOI:
10.1118/1.2826560
[Indexed for MEDLINE]
Free PMC Article
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