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Am J Hematol. 2008 Jul;83(7):574-6. doi: 10.1002/ajh.21176.

Longitudinal analysis of pulmonary function in adults with sickle cell disease.

Author information

1
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. jfield@im.wustl.edu

Abstract

Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

PMID:
18383325
PMCID:
PMC3729267
DOI:
10.1002/ajh.21176
[Indexed for MEDLINE]
Free PMC Article

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