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Pediatr Pulmonol. 2008 May;43(5):511-3. doi: 10.1002/ppul.20791.

Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure.

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Departments of Pediatrics and Internal Medicine, University of Kentucky College of Medicine, J410 Kentucky Clinic, 740 South Limestone Street, Lexington, Kentucky 40536, USA.


Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.

[Indexed for MEDLINE]

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