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Gynecol Endocrinol. 2008 Apr;24(4):230-4. doi: 10.1080/09513590801953465.

Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature.

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1
Department of Obstetrics and Gynaecology, Maulana Azad Medical College and associated L. N. Hospital, New Delhi, India.

Abstract

BACKGROUND:

Sertoli-Leydig cell tumor is a gonadal tumor of the sex cord-stromal type. It is a rare tumor comprising 0.1 to 0.5% of all ovarian tumors. Management of these cases poses a difficult therapeutic challenge.

CASE:

A 13-year-old girl presented with acute urinary retention, excessive hair growth and deepening of the voice. A mass the size of a 28-week gravid uterus was arising from the pelvis. Serum testosterone level was raised to 145.2 ng/dl. Computed tomography revealed a heterogeneously hypoechoic, solid cystic mass arising from the left adnexa. Left salpingo-oophorectomy was done. A histopathological diagnosis of Sertoli-Leydig cell tumor (intermediate, Meyers type II) was given.

CONCLUSION:

Patients with Sertoli-Leydig cell tumors present with signs of defeminization followed by masculinization. Age of the patient, stage of the disease and degree of tumor differentiation based on morphology are the most important factors to consider in the management of the case.

PMID:
18382911
DOI:
10.1080/09513590801953465
[Indexed for MEDLINE]
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