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Connect Tissue Res. 2008;49(2):68-75. doi: 10.1080/03008200801913502.

Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation.

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Laboratory of Genetics and Organogenesis, Research Division of the Hospital for Special Surgery, New York, New York, USA.


Collagen XXIV is an ill-characterized fibrillar collagen that is predominantly expressed in the forming skeleton of the mouse embryo. Here we report that the Col24al gene is constitutively transcribed in the trabecular bone and periosteum of the newborn mouse as well. The bone specificity of Col24al was further documented using three well-characterized cell culture models of osteoblast differentiation. These in vitro analyses indicated that Col24al transcription is activated at about the same time as that of the osteocalcin gene, and gradually increases to eventually plateau as osteoblasts begin to deposit a mineralizing matrix. These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix.

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