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J Immunotoxicol. 2008 Jan;5(1):59-68. doi: 10.1080/15476910802019086.

Pathogenic role of environmental toxins in immune-mediated liver diseases.

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  • 1Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA.


Immune-mediated liver diseases contribute significantly to morbidity and mortality due to liver failure and the need for liver transplantation. The pathogenesis of the immune-mediated chronic liver diseases, primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cirrhosis, is poorly understood. Genetic susceptibility factors may play a role, but increasing attention is being given to the association between environmental factors and these diseases. The existence of such a relationship is supported by epidemiologic surveys, animal models, and geographic clustering analyses. Unearthing the cause of this association may provide insight into the pathogenesis of immune-mediated chronic liver diseases and autoimmunity.

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