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Neuroreport. 2008 Apr 16;19(6):609-13. doi: 10.1097/WNR.0b013e3282fa6db9.

Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia.

Author information

1
Department of Psychiatry, Seoul National University College of Medicine, Hanyang University, Seoul, Korea.

Abstract

The authors performed a three-dimensional shape deformation analysis to clarify the various patterns of specific thalamic nuclei abnormality using three age-matched and sex-matched groups of 22 patients with obsessive-compulsive disorder (OCD), 22 patients with schizophrenia and 22 control participants. Compared with the healthy volunteers, the anterior, lateral outward surface deformities of the thalamus were significant in OCD patients, whereas the posterior, medial outward deformities of the thalamus were prominent in schizophrenia patients. In terms of thalamic asymmetry, both OCD and schizophrenia patients exhibited the loss of a leftward pattern of asymmetry on the posterior, medial surface of the thalamus. Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia.

PMID:
18382272
DOI:
10.1097/WNR.0b013e3282fa6db9
[Indexed for MEDLINE]

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