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Trends Biochem Sci. 1991 Dec;16(12):463-7.

Selenoprotein synthesis: an expansion of the genetic code.

Author information

1
Lehrstuhl für Mikrobiologie, Universität München, FRG.

Abstract

A number of enzymes employ the unusual amino acid selenocysteine as part of their active site because of its high chemical reactivity. Selenocysteine is incorporated into these proteins co-translationally: biosynthesis occurs on a specific tRNA and insertion into a growing polypeptide is directed by a UGA codon in the mRNA. In E. coli, this requires a specific translation factor. Selenocysteine thus represents a unique expansion of the genetic code.

PMID:
1838215
[Indexed for MEDLINE]

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