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Mov Disord. 2008 May 15;23(7):1013-1018. doi: 10.1002/mds.22013.

Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study.

Huang X1, Abbott RD2,3,4, Petrovitch H4,5,6,7, Mailman RB1,8,9, Ross GW4,5,6,7.

Author information

1
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
2
Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
3
Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan.
4
The Pacific Health Research Institute and the Kuakini Medical Center, Honolulu, Hawaii, USA.
5
Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA.
6
Department of Geriatric Medicine, University of Hawaii John A Burns School of Medicine, Honolulu, Hawaii, USA.
7
Department of Medicine, University of Hawaii John A Burns School of Medicine, Honolulu, Hawaii, USA.
8
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
9
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Abstract

Low-density lipoprotein cholesterol (LDL-C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL-C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu-Asia Aging Study) for whom the LDL-C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow-up, 41 men developed PD (18.4/10,000 person-years). Although the incidence of PD increased with decreasing LDL-C in a dose-dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person-years in men with LDL-C levels <80 mg/dl to less than 9/10,000 person-years for concentrations that were > or =140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL-C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD.

PMID:
18381649
DOI:
10.1002/mds.22013
[Indexed for MEDLINE]

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