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Org Lett. 2008 May 1;10(9):1807-10. doi: 10.1021/ol800397z. Epub 2008 Apr 2.

Synthesis of homochiral dihydroxy-4-nitroisoxazolines via one-pot asymmetric dihydroxylation-reduction.

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1
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medical Chemistry, The Royal College of Surgeons in Ireland, Dublin, Ireland. madamo@rcsi.ie

Abstract

Herein we report a one-pot procedure to prepare a family of homochiral dihydroxy-4-nitroisoxazolines 3. This new methodology affords the title compounds in good yields, excellent enantiopurity, and without the use of chromatography.

PMID:
18380439
DOI:
10.1021/ol800397z
[Indexed for MEDLINE]
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