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Adv Exp Med Biol. 2007;623:161-74.

Regulation of alternative splicing by signal transduction pathways.

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Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75390-9038, USA.


Alternative splicing is now recognized as a ubiquitous mechanism for controlling gene expression in a tissue-specific manner. A growing body of work from the past few years as begun to also highlight the existence of networks of signal-responsive alternative splicing in a variety of cell types. While the mechanisms by which signal transduction pathways influence the splicing machinery are relatively poorly understood, a few themes have begun to emerge for how extracellular stimuli can be communicated to specific RNA-binding proteins that control splice site selection by the spliceosome. This chapter describes our current understanding of signal-induced alternative splicing with an emphasis on these emerging themes and the likely directions for future research.

[Indexed for MEDLINE]

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