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Ocul Immunol Inflamm. 2008 Jan-Feb;16(1):29-33. doi: 10.1080/09273940801899764.

Intravitreal methotrexate resistance in a patient with primary intraocular lymphoma.

Author information

  • 1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. nidasen@gwu.edu

Abstract

PURPOSE:

To describe the clinical course of a patient with multiple recurrences of primary intraocular lymphoma (PIOL).

DESIGN:

Interventional case report,

METHODS:

Retrospective chart review.

RESULTS:

A 57-year-old female treated with multiple intravitreal methotrexate injections became refractory to intravitreal methotrexate after a year. Lymphoma cells evaluated using immunocytochemistry and confocal microscopy showed aberrant multidrug resistance-related protein (MRP) and decreased reduced folate carrier (RFC) and folate binding protein (FBP) expression compared to PIOL cells from another patient clinically responsive to methotrexate.

CONCLUSIONS:

This case suggests that alterations in the transport of methotrexate across the cell membrane might contribute to resistance following repeated intravitreal injections.

PMID:
18379939
PMCID:
PMC2561282
DOI:
10.1080/09273940801899764
[PubMed - indexed for MEDLINE]
Free PMC Article
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