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Clin Calcium. 2008 Apr;18(4):438-46. doi: CliCa0804438446.

[Mechanisms for formation of myeloma bone disease].

[Article in Japanese]

Author information

1
University of Tokushima Graduate School of Medicine, Department of Medicine and Bioregulatory Sciences.

Abstract

Myeloma cells stimulate bone resorption by enhancing osteoclast formation and suppress bone formation by inhibiting osteoblast differentiation. Macrophage inflammatory protein (MIP)-1alpha and MIP-1beta as well as RANK ligand play a major role in the enhancement of bone resorption in myeloma. Myeloma cell-derived soluble Wnt inhibitors as well as TGF-beta released from the bone tissues through enhanced bone resorption are thought to suppress osteoblast differentiation. Such pathognomonically skewed cellular components in the bone marrow create a microenvironment suitable for myeloma cell growth and survival (a myeloma niche) , which should be targeted to suppress myeloma expansion along with amelioration of bone lesions.

PMID:
18379024
DOI:
CliCa0804438446
[Indexed for MEDLINE]
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