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J Cell Biol. 2008 Apr 7;181(1):9-13. doi: 10.1083/jcb.200802155. Epub 2008 Mar 31.

Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging.

Author information

1
Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. meshorer@cc.huji.ac.il

Abstract

Specific mutations in the human gene encoding lamin A or in the lamin A-processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.

PMID:
18378774
PMCID:
PMC2287275
DOI:
10.1083/jcb.200802155
[Indexed for MEDLINE]
Free PMC Article

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