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Bioorg Med Chem Lett. 2008 Apr 15;18(8):2544-8. doi: 10.1016/j.bmcl.2008.03.049. Epub 2008 Mar 20.

Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists.

Author information

1
Drug Discovery, Johnson & Johnson PRD, East Coast RED, Spring House, PA 19477-0776, USA. kbarbay@prdus.jnj.com

Abstract

A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported. Synthetic routes were developed that allow the substituents on the tetrahydroquinoline core to be efficiently varied, facilitating determination of structure-activity relationships. Members of the series display high binding affinity for the C5a receptor and are potent functional antagonists.

PMID:
18378452
DOI:
10.1016/j.bmcl.2008.03.049
[Indexed for MEDLINE]

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