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Parasitology. 2008 May;135(6):683-90. doi: 10.1017/S0031182008004344. Epub 2008 Apr 1.

An experimental model for fatal malaria due to TNF-alpha-dependent hepatic damage.

Author information

1
Instituto Gulbenkian de Ciência, Oeiras, Portugal. eseixas@igc.gulbenkian.pt

Abstract

While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death.

PMID:
18377697
DOI:
10.1017/S0031182008004344
[Indexed for MEDLINE]

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