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Congenit Heart Dis. 2007 Jul-Aug;2(4):250-5. doi: 10.1111/j.1747-0803.2007.00105.x.

Congenital heart defects and fetal alcohol spectrum disorders.

Author information

1
Department of Pediatrics, Univrsity of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA. laburd@medicine.nodak.edu

Abstract

OBJECTIVE:

Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD).

DESIGN:

We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources.

RESULTS:

We found 29 studies that met our inclusion criteria. In the 12 case series studies of subjects with FASD, the proportion of cases with a CHD (atrial [ASD] and ventricular [VSD] septal defects, other defects, or unspecified CHD) ranged from 33% to 100%. From the 14 retrospective studies, the rate of septal defects was 21%, other structural defects 6% and unspecified defects was 12%. For the 2 case-control studies, the odds of CHD ranged from 1.0 (subjects with fetal alcohol effect) to 18.0 (subjects with fetal alcohol syndrome). In the 1 prospective study of CHD the OR for a child to have CHD and FASD was 1.0.

KEY CONCLUSION:

Pediatric cardiologists may have frequent contact with children with FASD and increased levels of attention to prenatal alcohol exposure as a potential etiology of CHD is indicated.

[Indexed for MEDLINE]

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