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Congenit Heart Dis. 2007 May-Jun;2(3):214-7. doi: 10.1111/j.1747-0803.2007.00101.x.

Polyvalvular disease in a fetus with normal chromosomes.

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Cedars-Sinai Medical Center-Pediatric Cardiology, Los Angeles, California 90048, USA.

Erratum in

  • Congenit Heart Dis. 2007 Jul;2(4):285.


Congenital polyvalvular disease is a spectrum of macroscopic and microscopic anomalies of the 4 valves of the heart. It is most commonly associated with chromosomal abnormalities, such as trisomy 13 and trisomy 18. Kowal-Vern et al. and Bartram et al. describe a total of 4 cases of congenital polyvalvular disease in patients with normal chromosomes by standard banding pattern analysis. Each of their patients, however, had associated extracardiac anomalies. Of the 8 previously reported cases of congenital polyvalvular disease with no extracardiac anomalies, chromosome analysis was not performed. We report a prenatally diagnosed case of polyvalvular disease with normal chromosomes and no extracardiac anomalies.

[Indexed for MEDLINE]

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