Format

Send to

Choose Destination
See comment in PubMed Commons below
Congenit Heart Dis. 2007 Sep-Oct;2(5):288-300. doi: 10.1111/j.1747-0803.2007.00116.x.

Protein-losing enteropathy after Fontan operation.

Author information

1
The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. rychik@email.chop.edu

Abstract

Protein-losing enteropathy (PLE) is a poorly understood and enigmatic disease process affecting patients with single ventricle after Fontan operation. In those afflicted, PLE after Fontan operation results in significant morbidity and mortality. The pathophysiology of the disease is unknown; however, a proposed mechanism incorporates a combination of phenomena including: (1) altered hemodynamics, specifically low cardiac output; (2) increased mesenteric vascular resistance; (3) systemic inflammation; and (4) altered enterocyte basal membrane glycosaminoglycan make-up. A paradigm for the clinical management of PLE after Fontan operation is proposed.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center