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Expert Rev Vaccines. 2007 Dec;6(6):949-56. doi: 10.1586/14760584.6.6.949.

Current progress of adhesins as vaccine candidates for Moraxella catarrhalis.

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  • 1Malmö University Hospital, Medical Microbiology, Department of Laboratory Medicine, Lund University, SE-205 02 Malmö, Sweden.


Moraxella catarrhalis is an emerging pathogen and all isolates are now considered beta-lactamase producing. Potential further use of vaccines against Streptococcus pneumoniae and nontypeable Haemophilus influenzae means that M. catarrhalis might be thrust further into the limelight. However, a vaccine has not yet been designed. In this review, the progress of M. catarrhalis adhesins as vaccine candidates is discussed with a focus on various candidate antigens that spanned those discovered more than 10 years ago, for example, the ubiquitous surface proteins to newer antigens, such as the Moraxella IgD-binding hemagglutinin.

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