Format

Send to

Choose Destination
Zebrafish. 2006;3(4):415-29. doi: 10.1089/zeb.2006.3.415.

Conditional transgene and gene targeting methodologies in zebrafish.

Author information

1
Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.

Abstract

The zebrafish has become a powerful tool for dissecting vertebrate gene function during embryogenesis. Numerous molecular systems have been developed to examine gene function in zebrafish, including transgenics for creating lineage-tracer lines of zebrafish that express a fluorescent protein as a marker for specific populations of cells, and antisense strategies, primarily morpholinos, for knocking down gene function. The focus of this review is to summarize the pros and cons of the currently available systems for functional genomics in zebrafish, and to discuss the need for future methodologies.

PMID:
18377222
DOI:
10.1089/zeb.2006.3.415

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center