Format

Send to

Choose Destination
See comment in PubMed Commons below

[Identification of proteins determining the virulence of Listeria monocytogenes using the bioinformation analysis].

[Article in Russian]

Abstract

The postgenomic stage of biotechnology allows the bioinformation approaches to be used for revealing previously unknown factors involved in different processes. In this work, bioinformation approaches were applied to analysis of factors involved in the L. monocytogenes virulence. Several open reading frames (ORFs) were identified in L. monocytogenes genome, which encode proteins with high level homology to bacterial peptidases and which meets the developed criteria. The influence of the ORFs on virulence was demonstrated by infection of mice with L. monocytogenes strains mutated in the studied genes. Growth rates, morphology, and production of surface proteins characterized the obtained strains.

PMID:
18376476
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center