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Pancreas. 2008 Mar;36(2):197-9. doi: 10.1097/MPA.0b013e3181594258.

Interleukin 22 receptor 1 expression in pancreas islets.

Author information

1
Department of Medicine, Shiga University of Medical Science, Otsu, Japan.

Abstract

OBJECTIVES:

Interleukin (IL) 22 is a recently identified T-cell-derived cytokine. IL-22 binds at the cell surface to a heterodimer receptor complex composed of IL-22 receptor (R) 1 and IL-10R2. In this study, we performed immunohistochemical analyses for IL-22R1 expression in human pancreatic tissue.

METHODS:

Normal human pancreatic tissue (n = 8) was immunostained with antihuman IL-22R1 antibodies following standard immunohistochemical procedures.

RESULTS:

In the normal human pancreas, IL-22R1 was expressed in the islets of Langerhans. IL-22R1 was not expressed by the acinar cells and ductal epithelium. Double-immunostaining experiments showed that the majority of insulin-expressing beta cells and glucagon-expressing alpha cells were immunopositive for IL-22R1.

CONCLUSIONS:

The islets of Langerhans are the local site for IL-22R1 expression in the human pancreas. It may be that the T-cell-mediated immune response modulates cell islet function through IL-22 signaling.

PMID:
18376313
DOI:
10.1097/MPA.0b013e3181594258
[Indexed for MEDLINE]
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