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Exp Biol Med (Maywood). 2008 May;233(5):496-506. doi: 10.3181/0708-MR-231. Epub 2008 Mar 28.

Nuclear receptors and inflammatory diseases.

Author information

1
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA. ywan@kumc.edu

Abstract

It is well known that the steroid hormone glucocorticoid and its nuclear receptor regulate the inflammatory process, a crucial component in the pathophysiological process related to human diseases that include atherosclerosis, obesity and type II diabetes, inflammatory bowel disease, Alzheimer's disease, multiple sclerosis, and liver tumors. Growing evidence demonstrates that orphan and adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors, liver x receptors, the farnesoid x receptor, NR4As, retinoid x receptors, and the pregnane x receptor, regulate the inflammatory and metabolic profiles in a ligand-dependent or -independent manner in human and animal models. This review summarizes the regulatory roles of these nuclear receptors in the inflammatory process and the underlying mechanisms.

PMID:
18375823
PMCID:
PMC3991236
DOI:
10.3181/0708-MR-231
[Indexed for MEDLINE]
Free PMC Article
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