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Biochem Biophys Res Commun. 2008 Jun 6;370(3):410-3. doi: 10.1016/j.bbrc.2008.03.099. Epub 2008 Mar 28.

Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage.

Author information

1
Dulbecco Telethon Institute, Molecular Genetics of Renal Disorders, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

Abstract

Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain.

PMID:
18375198
DOI:
10.1016/j.bbrc.2008.03.099
[Indexed for MEDLINE]

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