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Joint Bone Spine. 2008 May;75(3):273-9. doi: 10.1016/j.jbspin.2007.09.010. Epub 2008 Mar 28.

Pathogenesis of fibromyalgia - a review.

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Department of Rheumatology, Institute of Rheumatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizman St., Tel-Aviv University, Tel-Aviv 64239, Israel.


Fibromyalgia, a syndrome characterized by widespread pain and diffuse tenderness, is considered a multifactorial disorder. Central nervous system sensitization is a major pathophysiological aspect of fibromyalgia, while various external stimuli such as infection, trauma and stress may contribute to development of the syndrome. In addition, current evidence points towards the existence of a genetic basis for fibromyalgia and information has been accumulated regarding the role of a number of candidate genes in fibromyalgia pathogenesis. In the present review, we have summarized the clinical manifestations of fibromyalgia, as well as the necessary laboratory workup; subsequently we have attempted to cover various aspects of pathogenesis with special emphasis on the genetic aspects currently uncovered.

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