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Vaccine. 2008 Apr 16;26(17):2073-80. doi: 10.1016/j.vaccine.2008.02.046. Epub 2008 Mar 13.

In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY).

Author information

1
Immunology Research Institute, GHEN Corporation, 839-1 Sano, Gifu 501-1101, Japan. ibrahim@ghen.co.jp

Abstract

We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness. Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner. The protective efficacy of anti-CA IgY was investigated in experimentally induced oral candidiasis in immunosuppressed mice. Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions. Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs. These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans. Putting together, these results indicate that anti-CA IgY is effective against C. albicans. This effect might be due to the blocking of the binding of C. albicans to the host cells. Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal therapy.

PMID:
18375022
DOI:
10.1016/j.vaccine.2008.02.046
[Indexed for MEDLINE]

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