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Lancet. 2008 Mar 29;371(9618):1126-35. doi: 10.1016/S0140-6736(08)60489-4.

Contributions of non-human primates to neuroscience research.

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California National Primate Research Center and Department of Psychology, University of California, Davis, CA 95616, USA.


Non-human primates have a small but important role in basic and translational biomedical research, owing to similarities with human beings in physiology, cognitive capabilities, neuroanatomy, social complexity, reproduction, and development. Although non-human primates have contributed to many areas of biomedical research, we review here their unique contributions to work in neuroscience, and focus on four domains: Alzheimer's disease, neuroAIDS, Parkinson's disease, and stress. Our discussion includes, for example, the role of non-human primates in development of new treatments (eg, stem cells, gene transfer) before phase I clinical trials in patients; basic research on disease pathogenesis; and understanding neurobehavioural outcomes resulting from genotype-environment interactions.

[Indexed for MEDLINE]

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