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Genome Biol. 2008;9(3):214. doi: 10.1186/gb-2008-9-3-214. Epub 2008 Mar 28.

Cytoplasmic dynein could be key to understanding neurodegeneration.

Author information

1
Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK. g.banks@prion.ucl.ac.uk.

Abstract

A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase.

PMID:
18373888
PMCID:
PMC2397497
DOI:
10.1186/gb-2008-9-3-214
[Indexed for MEDLINE]
Free PMC Article
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