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J Theor Biol. 2008 Jun 21;252(4):633-48. doi: 10.1016/j.jtbi.2008.01.032. Epub 2008 Feb 16.

A virtual look at Epstein-Barr virus infection: simulation mechanism.

Author information

1
Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.

Abstract

Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.

PMID:
18371986
PMCID:
PMC2515170
DOI:
10.1016/j.jtbi.2008.01.032
[Indexed for MEDLINE]
Free PMC Article

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