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Cell Stem Cell. 2007 Dec 13;1(6):599-600. doi: 10.1016/j.stem.2007.11.010.

Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0.

Author information

1
Haverford College, Haverford, PA 19041, USA. semerson@haverford.edu

Abstract

New findings in this issue of Cell Stem Cell by Qian et al. (2007) and Yoshihara et al. (2007) reveal that thrombopoietin modulates hematopoietic stem cell (HSC) cell-cycle progression at the osteoblast surface, linking a single cytokine with a specific postnatal niche cell. These observations indicate that simultaneous stimulation and suspension in a G(0) state are critical for maintenance of the HSC pool.

PMID:
18371399
DOI:
10.1016/j.stem.2007.11.010
[Indexed for MEDLINE]
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