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FEMS Microbiol Lett. 2008 May;282(2):238-40. doi: 10.1111/j.1574-6968.2008.01126.x. Epub 2008 Mar 27.

Contribution of extended-spectrum AmpC (ESAC) beta-lactamases to carbapenem resistance in Escherichia coli.

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1
Service de Bactériologie-Hygiène, Centre Hospitalier Universitaire d'Amiens, Hôpital Nord, Amiens, France. hedi.mammeri@bct.aphp.fr

Abstract

ESAC beta-lactamases have increased catalytic efficiencies toward extended-spectrum cephalosporins and to a lesser extent toward imipenem as compared with the wild-type cephalosporinases. We show here that ESAC expression associated with the loss of both OmpC and OmpF porins conferred in Escherichia coli a high level of resistance to ertapenem and reduced the susceptibility to imipenem. On the contrary, ESAC expressed in the OmpC- or OmpF-deficient E. coli strains or narrow-spectrum cephalosporinase expressed in the OmpC-and OmpF-deficient strain do not confer reduced susceptibility to any of the carbapenems. The production of ESAC beta-lactamase in favorable E. coli background may represent an additional mechanism of resistance to ertapenem.

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