Format

Send to

Choose Destination
See comment in PubMed Commons below
Methods Mol Biol. 2008;415:379-94. doi: 10.1007/978-1-59745-570-1_22.

Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways.

Author information

1
Centre de Génétique Moléculaire du CNRS, Gif-sur-Yvette, France.

Abstract

Invertebrates lack an adaptive immune system and rely on innate immunity to resist pathogens. The response of Drosophila melanogaster to bacterial and fungal infections involves two signaling pathways, Toll and Imd, both of which activate members of the nuclear factor (NF)-kappaB family of transcription factors, leading to antimicrobial peptide (AMP) gene expression. In this chapter, we present the current methods used in our laboratory to monitor the activity of both signaling pathways.

PMID:
18370166
DOI:
10.1007/978-1-59745-570-1_22
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center