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Methods Mol Biol. 2008;415:1-16. doi: 10.1007/978-1-59745-570-1_1.

ENU mutagenesis in mice.

Author information

1
Laboratoire d'Immunogénétique Moléculaire Humaine, Centre de Recherche en Immunologie et Hématologie, Faculté de Médecine, Strasbourg Cedex, France.

Abstract

Forward genetics has led to many "breakthrough" discoveries, and with the mouse genome almost fully sequenced, the creation of phenotypes through random germline mutagenesis has become an efficient means by which to find the function of yet undescribed genes. In this chapter, we will provide a practical guideline for performing germline mutagenesis in mice. In particular, we will focus on the application of this technology to identify genes that are essential to innate immune defense.

PMID:
18370145
DOI:
10.1007/978-1-59745-570-1_1
[Indexed for MEDLINE]

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