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Eur Arch Otorhinolaryngol. 2009 Feb;266(2):297-9. doi: 10.1007/s00405-008-0636-6. Epub 2008 Mar 28.

Leser-Trelat sign in metastasized malignant melanoma.

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Department of Otorhinolaryngology, Ludwig-Maximilian University, Marchioninistr. 15, 81377 Munich, Germany.


The Leser-Trelat sign is defined as the association of multiple, eruptive seborrheic keratoses with an internal malignancy of a usually advanced stage. We report the case of malignant melanoma in an 82-year-old man covered with hundreds of greyish-dark seborrheic keratoses resembling a Christmas tree pattern, who was diagnosed with metastasized malignant melanoma involving the parotid gland and lymph nodes. Though the pathogenesis of Leser-Trelat sign is still unknown, spontaneous regression of the seborrheic keratoses following tumor reduction described in some cases argues for a paraneoplastic origin of this highly instructive clinical entity. Physicians should consider a workup for internal malignancy in patients presenting with multiple eruptive seborrheic keratoses.

[Indexed for MEDLINE]

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