Format

Send to

Choose Destination
See comment in PubMed Commons below
Rheumatol Int. 2008 Aug;28(10):1031-4. doi: 10.1007/s00296-008-0563-2. Epub 2008 Mar 28.

Safety and efficacy of etanercept in children with juvenile idiopathic arthritis below the age of 4 years.

Author information

  • 1University Children's Hospital, Tuebingen, Germany. nikolay.tzaribachev@med.uni-tuebingen.de

Abstract

Little is known about the safety and efficacy of etanercept in children below the age of 4 years. Twenty-five patients with juvenile idiopathic arthritis (JIA) below the age of 4 years, who received etanercept, were documented in the German JIA Etanercept Registry. Patients with the nonsystemic JIA disease-subtype responded more frequently to treatment with etanercept than systemic onset patients. At last observation, two (20%) of the nonsystemic patients did not reach a PedACR 30 response, while six (40%) of the systemic onset patients did not respond to the therapy. Complete resolution of symptoms was observed in two (20%) nonsystemic and in five (33%) systemic onset patients with JIA. Tolerability was good with only two infections occurring in the total patients group. Patients with JIA below the age of 4 years, with a methotrexate-resistant disease course, would also benefit from treatment with etanercept, showing a good tolerability. The restriction to children older than 4 years appears to be artificial without any good rationale.

PMID:
18369626
DOI:
10.1007/s00296-008-0563-2
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center