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Science. 2008 Mar 28;319(5871):1785-6. doi: 10.1126/science.1151651.

Gene regulation by transcription factors and microRNAs.

Author information

  • 1Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA. or38@columbia.edu

Abstract

The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor- and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.

PMID:
18369135
DOI:
10.1126/science.1151651
[PubMed - indexed for MEDLINE]
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