Send to

Choose Destination
Dig Dis Sci. 2008 Nov;53(11):2925-8. doi: 10.1007/s10620-008-0242-x. Epub 2008 Mar 27.

Effect of gluten-free diet on pregnancy outcome in celiac disease patients with recurrent miscarriages.

Author information

Lorenzo Bonomo Hospital, Via Torino, 49, 70031, Andria, BA, Italy.



Available literature data show that celiac disease (CD) is a frequent cause of recurrent miscarriage. However, data are lacking for pregnancy outcome when the patient is on a gluten-free diet (GFD). A case-control study about the effect of GFD on pregnancy was conducted from 1995 to 2006. A cohort of 13 women (mean age 32 years, range 22-38 years) affected by CD with recurrent miscarriages was observed. In all of them several causes of miscarriage (gynecological, endocrine, hematological, etc.) were excluded. All patients were started on a gluten-free diet and were reassessed throughout a long-term follow-up period to evaluate the outcome of pregnancy.


Six of 13 became pregnant (46.15%) as follows: 1 patient (7.69%) 1 year after GFD was started, 3 patients (23.07%) 2 years after GFD was started, 1 patient (7.69%) after 3 years, and finally 1 (7.69%) 4 years after GFD was started. Moreover, two patients (16.66%) had multiple pregnancies (one had had two childbirths and another had undergone three births within a 7-year follow-up period under GFD).


GFD seems to favor a positive outcome of pregnancy in most CD patients with recurrent miscarriage.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center