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Nat Rev Genet. 2008 May;9(5):397-405. doi: 10.1038/nrg2337.

Transposable elements and the evolution of regulatory networks.

Author information

1
Department of Biology, Life Science Building, BOX 19498, University of Texas, Arlington, Texas 76019, USA. cedric@uta.edu

Abstract

The control and coordination of eukaryotic gene expression rely on transcriptional and post-transcriptional regulatory networks. Although progress has been made in mapping the components and deciphering the function of these networks, the mechanisms by which such intricate circuits originate and evolve remain poorly understood. Here I revisit and expand earlier models and propose that genomic repeats, and in particular transposable elements, have been a rich source of material for the assembly and tinkering of eukaryotic gene regulatory systems.

PMID:
18368054
PMCID:
PMC2596197
DOI:
10.1038/nrg2337
[Indexed for MEDLINE]
Free PMC Article

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