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Autophagy. 2008 May;4(4):402-3. Epub 2008 Mar 18.

The role of autophagy during ischemia/reperfusion.

Author information

1
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA. Sadoshju@umdnj.edu

Abstract

Ischemia (hypoxia)/reperfusion (I/R) primarily caused by atherosclerosis and thrombosis, induces tissue injury and organ malfunction, and is therefore, an important clinical problem. Understanding the cellular mechanisms of enhancing cell survival or preventing cell death during I/R could lead to development of strategies to treat this health problem.

PMID:
18367869
DOI:
10.4161/auto.5924
[Indexed for MEDLINE]

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