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Nat Clin Pract Oncol. 2008 May;5(5):291-5. doi: 10.1038/ncponc1105. Epub 2008 Mar 25.

Five donors-one recipient: modeling a mosaic of granulocytes, natural killer and T cells from cord-blood and third-party donors.

Author information

1
Department of Internal Medicine II, University of Würzburg, Germany.

Abstract

BACKGROUND:

A 21-year-old man was admitted to hospital because of leukocytosis, thrombocytopenia and anemia. The patient had been in good health until a few days earlier, when he developed fever and night sweats and his performance status dramatically declined.

INVESTIGATIONS:

Laboratory tests, immunophenotyping, cytogenetic analyses, bone-marrow biopsy, minimal residual disease analysis using quantitative real-time polymerase chain reaction, differential chimerism analysis using flow cytometry, mixed chimerism analysis, CT scans, electro-encephalography, cerebral magnetic resonance tomography.

DIAGNOSIS:

Bcr-abl-positive and Philadelphia-chromosome-positive acute lymphoblastic leukemia, and primary graft failure complicated by invasive fungal infection and cytomegalovirus encephalitis.

MANAGEMENT:

Double cord-blood rescue transplantation, third-party CD34-positive stem-cell rescue transplantation, third-party cytomegalovirus-specific T lymphocyte transplantation.

PMID:
18364724
DOI:
10.1038/ncponc1105
[Indexed for MEDLINE]

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