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Immunol Rev. 2008 Apr;222:180-91. doi: 10.1111/j.1600-065X.2008.00608.x.

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.

Author information

1
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Abstract

Patients with cancer have an impaired T-cell response that can decrease the potential therapeutic benefit of cancer vaccines and other forms of immunotherapy. L-arginine (L-Arg) is a conditionally essential amino acid that is fundamental for the function of T lymphocytes. Recent findings in tumor-bearing mice and cancer patients indicate that increased metabolism of L-Arg by myeloid derived suppressor cells (MDSCs) producing arginase I inhibits T-lymphocyte responses. Here we discuss some of the most recent concepts how MDSC expressing arginase I may regulate T-cell function in cancer and other chronic inflammatory diseases and suggest possible therapeutic interventions to overcome this inhibitory effect.

PMID:
18364002
PMCID:
PMC3546504
DOI:
10.1111/j.1600-065X.2008.00608.x
[Indexed for MEDLINE]
Free PMC Article

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