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Exerc Sport Sci Rev. 2008 Apr;36(2):51-7. doi: 10.1097/JES.0b013e318168e9dc.

Nuclear apoptosis contributes to sarcopenia.

Author information

1
Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506-9227, USA. salway@hsc.wvu.edu

Abstract

Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.

PMID:
18362685
PMCID:
PMC2778230
DOI:
10.1097/JES.0b013e318168e9dc
[Indexed for MEDLINE]
Free PMC Article

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