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Autophagy. 2008 Jul;4(5):567-73. Epub 2008 Mar 13.

The selectivity of autophagy and its role in cell death and survival.

Author information

1
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-1892, USA.

Abstract

Autophagy is a cellular process whose primary function is to degrade long-lived proteins and recycle cellular components. Beside macroautophagy, there are several forms of selective autophagy, including chaperone-mediated autophagy (CMA), cytoplasm to vacuole targeting (Cvt), pexophagy and mitophagy. In this review, we summarize what is currently known about selective autophagy, and discuss its role in cell death and survival. We also discuss possible mechanisms underlying the selectivity of macroautophagy.

PMID:
18362514
DOI:
10.4161/auto.5902
[Indexed for MEDLINE]

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