Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Microbiol. 2008 Apr;11(2):100-5. doi: 10.1016/j.mib.2008.02.001. Epub 2008 Mar 24.

Control of bacterial transcription, translation and replication by (p)ppGpp.

Author information

  • 1Department of Molecular and Human Genetics, One Baylor Plaza, Room S-911, Mail Stop 225, Baylor College of Medicine, Houston, TX 77030, United States.


The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response to nutritional stress. In Escherichia coli, the enzymes RelA and SpoT are triggered by different starvation signals to produce (p)ppGpp. In many Gram-positive bacteria this is carried out by RelA and two small homologs. (p)ppGpp, along with the transcription factor DksA, has profound effects on transcription initiation in E. coli. (p)ppGpp/DksA exert differential effects on promoters by playing upon their intrinsic kinetic parameters, and by facilitating the utilization of alternative sigma factors. (p)ppGpp also regulates replication and translation. These studies highlight (p)ppGpp as a key factor in bacterial physiology that responds rapidly to diverse stresses, by shutting down growth and priming cellular defensive and adaptive processes.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center