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Otolaryngol Head Neck Surg. 2008 Apr;138(4):492-6. doi: 10.1016/j.otohns.2007.11.027.

Tinnitus treatment with memantine.

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1
OTOSUL-Otorrinolaringologia Sul-Fluminense. rfigueiredo@otosul.com.br

Abstract

OBJECTIVE:

To evaluate efficacy and safety of memantine in the treatment of tinnitus.

STUDY DESIGN:

Prospective, randomized, double-blind crossover study.

SUBJECTS AND METHODS:

A total of 60 patients with tinnitus were randomized into a double-blind, placebo-controlled, prospective crossover study. Patients each received up to 20 mg memantine and placebo for 90 days, separated by a 30-day washout period. Treatment effects were assessed by using the Tinnitus Handicap Inventory (THI). A total of 43 patients completed the trial.

RESULTS:

There was no significant improvement of THI score after memantine treatment compared with placebo. A possible tendency for delayed effects of memantine was observed. The incidence of side effects during memantine treatment was 9.4 percent, leading to interruption of treatment in all cases.

CONCLUSION:

This study does not provide evidence to recommend memantine for the treatment of tinnitus. A possible late effect of the drug should be evaluated in further studies with longer observation periods.

PMID:
18359360
DOI:
10.1016/j.otohns.2007.11.027
[Indexed for MEDLINE]
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