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J Clin Epidemiol. 2008 Jul;61(7):705-13. doi: 10.1016/j.jclinepi.2007.08.016. Epub 2008 Mar 21.

Determination of the minimal clinically important difference for seven fatigue measures in rheumatoid arthritis.

Author information

1
Arthritis Research Centre of Canada, Division of Rheumatology, University of British Columbia, Vancouver, BC, Canada. jacques.pouchot@egp.aphp.fr

Abstract

OBJECTIVE:

To estimate the minimal clinically important difference (MCID) of seven measures of fatigue in rheumatoid arthritis.

STUDY DESIGN AND SETTING:

A cross-sectional study design based on interindividual comparisons was used. Six to eight subjects participated in a single meeting and completed seven fatigue questionnaires (nine sessions were organized and 61 subjects participated). After completion of the questionnaires, the subjects had five one-on-one 10-minute conversations with different people in the group to discuss their fatigue. After each conversation, each patient compared their fatigue to their conversational partners on a global rating. Ratings were compared to the scores of the fatigue measures to estimate the MCID. Both nonparametric and linear regression analyses were used.

RESULTS:

Nonparametric estimates for the MCID relative to "little more fatigue" tended to be smaller than those for "little less fatigue." The global MCIDs estimated by linear regression were: Fatigue Severity Scale, 20.2; Vitality scale of the MOS-SF36, 14.8; Multidimensional Assessment of Fatigue, 18.7; Multidimensional Fatigue Inventory, 16.6; Functional Assessment of Chronic Illness Therapy-Fatigue, 15.9; Chalder Fatigue Scale, 9.9; 10-point numerical Rating Scale, 19.7, for normalized scores (0-100). The standardized MCIDs for the seven measures were roughly similar (0.67-0.76).

CONCLUSION:

These estimates of MCID will help to interpret changes observed in a fatigue score and will be critical in estimating sample size requirements.

PMID:
18359189
PMCID:
PMC2486378
DOI:
10.1016/j.jclinepi.2007.08.016
[Indexed for MEDLINE]
Free PMC Article
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