Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations

Cancer Res. 1991 Dec 15;51(24):6712-4.

Abstract

Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Differentiation, T-Lymphocyte / genetics
  • Blotting, Northern
  • Blotting, Southern
  • CD3 Complex
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 19
  • Chromosomes, Human, Pair 4
  • Chromosomes, Human, Pair 9
  • Cloning, Molecular
  • DNA, Neoplasm / genetics
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • Receptors, Antigen, T-Cell / genetics
  • Restriction Mapping
  • Translocation, Genetic / genetics*

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • CD3 Complex
  • DNA, Neoplasm
  • RNA, Messenger
  • RNA, Neoplasm
  • Receptors, Antigen, T-Cell